Oncogenic KRAS(G12V) and BRAF(V600E) in intestinal organoids

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UID: 11050

Author(s): Riemer, Pamela, Morkel, Marcus

Description: Summary from GEO:

"Goals of the study was to compare transcripional and phenotypic response of mouse intestinal organoid cultures to the KRAS(G12V) or BRAF(V600E)oncogenes."

Overall design from GEO:

"Two biological replicates of organoids with transgenic luc-tdTomato, KRAS(G12V)-tdTomato, BRAF(V600E)-tdTomato were analysed by RNA-Seq. By comparing 7-10 x 10E7 50bp paired end reads per library we identify transcriptional alterations in the intestinal epithelium following expression of each oncogene."

Subject of Study

Subject(s)

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