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  • Pan-Cancer Atlas (PanCanAtlas)

    Description

    The Pan-Cancer Atlas (PanCanAtlas) initiative aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major...

    Subject
    Gene Expression Profiling
    Neoplasms/genetics
    Oncogenes
    Signal Transduction
    Access Rights
    Free to All
    Free to all with registration
  • Oncogenic KRAS(G12V) and BRAF(V600E) in intestinal organoids

    Authors
    Riemer, Pamela
    Morkel, Marcus
    Description

    Summary from GEO: "Goals of the study was to compare transcripional and phenotypic response of mouse intestinal organoid cultures to the KRAS(G12V) or BRAF(V600E)oncogenes." Overall design from GEO: "Two biological replicates of organoids with transgenic luc-tdTomato, KRAS(G12V)-tdTomato, BRAF(V600E)-tdTomato were analysed by RNA-Seq. By comparing 7-10 x 10E7 50bp paired end reads per library...

    Subject
    Epithelial Cells
    Genes, ras
    Oncogenes
    Proto-Oncogene Proteins B-raf
    RNA-Seq
    Access Rights
    Free to All