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  • Histiocytosis Cobimetinib (MSK, Nature 2019): Targeted and whole exome sequencing of 52 histiocytosis tumor/normal pairs

    Description

    This dataset contains the summary data visualizations and clinical data from targeted and whole exome sequencing of 52 histiocytosis tumor/normal pairs from 18 patients. Clinical data includes: Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Diagnosis Age, Sex, Primary/Metastasis Sample Type, Any dose reduction, Disease at Diagnosis, Duration of Treatment (Months), ECOG status,...

    Subject
    Erdheim-Chester Disease
    Histiocytosis
    Histiocytosis, Langerhans-Cell
    Histiocytosis, Sinus
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    Free to All
  • RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions

    Authors
    Berres, Marie-Luise
    Hogstad, Brandon
    Chakraborty, Rikhia
    Allen, Carl E
    1 more author(s)...
    Description

    Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...

    Subject
    bcl-X Protein
    Dendritic Cells
    Histiocytosis, Langerhans-Cell
    Mitogen-Activated Protein Kinase Kinases
    Proto-Oncogene Proteins B-raf
    Receptors, CCR7
    Access Rights
    Free to All