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Histiocytosis Cobimetinib (MSK, Nature 2019): Targeted and whole exome sequencing of 52 histiocytosis tumor/normal pairs
- Description
This dataset contains the summary data visualizations and clinical data from targeted and whole exome sequencing of 52 histiocytosis tumor/normal pairs from 18 patients. Clinical data includes: Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Diagnosis Age, Sex, Primary/Metastasis Sample Type, Any dose reduction, Disease at Diagnosis, Duration of Treatment (Months), ECOG status,...
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Erdheim-Chester DiseaseHistiocytosisHistiocytosis, Langerhans-CellHistiocytosis, Sinus
- Access Rights
- Free to All
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RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
- Authors
- Berres, Marie-LuiseHogstad, BrandonChakraborty, RikhiaAllen, Carl E1 more author(s)...
- Description
Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...
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bcl-X ProteinDendritic CellsHistiocytosis, Langerhans-CellMitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins B-rafReceptors, CCR7
- Access Rights
- Free to All