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Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas)
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 487 lung squamous cell carcinomas from 487 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...
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Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellDNA Mutational Analysis
- Access Rights
- Free to All
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Thoracic PDX (MSK, Provisional): Targeted sequencing of thoracic PDX lines to characterize genetic alterations in 139 tumor/normal pairs via MSK-IMPACT.
- Description
This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...
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Adenocarcinoma of LungCarcinoma, Non-Small-Cell LungDNA Mutational AnalysisLung NeoplasmsMesothelioma
- Access Rights
- Free to All
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TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...
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DNA Mutational AnalysisImmunotherapyMutationTumor Burden
- Access Rights
- Free to All
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Lung Squamous Cell Carcinoma (TCGA, Firehose Legacy)
- Description
TCGA Lung Squamous Cell Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 511 carcinomas from 511 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...
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Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellDNA Mutational AnalysisLung Neoplasms
- Access Rights
- Free to All
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Mixed cfDNA (MSKCC, 2020): IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal
- Description
This dataset contains the summary data visualizations and clinical data of IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal from 118 patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Sex, Primary/Metastasis Sample Type, Collaboration Id, Gene Panel, Oncotree Code, Tumor/cfDNA Sample...
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AdenocarcinomaAdenocarcinoma of LungBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, NeuroendocrineCarcinoma, Renal CellCarcinoma, Squamous CellCell-Free Nucleic AcidsChoriocarcinomaEndodermal Sinus TumorMelanomaNeoplasms, Germ Cell and EmbryonalNeoplasms, Squamous CellNeuroendocrine TumorsProstatic NeoplasmsSeminomaSmall Cell Lung CarcinomaUrinary Bladder Neoplasms
- Access Rights
- Free to All
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Non-Small Cell Lung Cancer (MSKCC, J Clin Oncol 2018): IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy.
- Description
This dataset contains the summary data visualizations and clinical data from IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy from 240 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Durable Clinical Benefit, FGA, Gene Panel, IRB, Lines of treatment, Mutation Rate, Oncotree Code, PD-L1 Score (%), Smoker,...
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Adenocarcinoma of LungCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung Neoplasms
- Access Rights
- Free to All
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Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [EPIC]
- Authors
- Quintanal Villalonga, Alvaro DiegoZhan, YingqianRudin, Charles M.
- Description
Summary from GEO: "To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation." Overall design from GEO: "We performed EPIC (methyl-capture) in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas."
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Adenocarcinoma of LungCarcinoma, Squamous CellMethylation
- Access Rights
- Free to All
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Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [RNA-seq]
- Authors
- Quintanal Villalonga, Alvaro DiegoZhan, YingqianRudin, Charles M.
- Description
Summary from GEO: "To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation." Overall design from GEO: "We performed RNAseq in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas."
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Adenocarcinoma of LungCarcinoma, Squamous CellRNA-Seq
- Access Rights
- Free to All
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Next Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases
- Authors
- Paik, Paul K.
- Description
Description from dbGaP: "Putative oncogenic pathways in squamous cell lung cancer have been recently characterized, although their biologic repercussions in patients is largely unknown. This study sought to discover potential clinical manifestations of major pathways in squamous cell lung cancer, particularly the PI3K pathway. Two key findings emerged: patients with stage IV squamous cell lung cancer...
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Brain NeoplasmsCarcinoma, Squamous CellLung NeoplasmsNeoplasm MetastasisRNA-SeqWhole Genome Sequencing
- Access Rights
- Application Required