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Results Found: 9
  • Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 487 lung squamous cell carcinomas from 487 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    DNA Mutational Analysis
    Access Rights
    Free to All
  • Thoracic PDX (MSK, Provisional): Targeted sequencing of thoracic PDX lines to characterize genetic alterations in 139 tumor/normal pairs via MSK-IMPACT.

    Description

    This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Non-Small-Cell Lung
    DNA Mutational Analysis
    Lung Neoplasms
    Mesothelioma
    Access Rights
    Free to All
  • TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...

    Subject
    DNA Mutational Analysis
    Immunotherapy
    Mutation
    Tumor Burden
    Access Rights
    Free to All
  • Lung Squamous Cell Carcinoma (TCGA, Firehose Legacy)

    Description

    TCGA Lung Squamous Cell Carcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 511 carcinomas from 511 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

    Subject
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    DNA Mutational Analysis
    Lung Neoplasms
    Access Rights
    Free to All
  • Mixed cfDNA (MSKCC, 2020): IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal

    Description

    This dataset contains the summary data visualizations and clinical data of IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal from 118 patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Sex, Primary/Metastasis Sample Type, Collaboration Id, Gene Panel, Oncotree Code, Tumor/cfDNA Sample...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Neuroendocrine
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Cell-Free Nucleic Acids
    Choriocarcinoma
    Endodermal Sinus Tumor
    Melanoma
    Neoplasms, Germ Cell and Embryonal
    Neoplasms, Squamous Cell
    Neuroendocrine Tumors
    Prostatic Neoplasms
    Seminoma
    Small Cell Lung Carcinoma
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Non-Small Cell Lung Cancer (MSKCC, J Clin Oncol 2018): IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy.

    Description

    This dataset contains the summary data visualizations and clinical data from IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy from 240 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Durable Clinical Benefit, FGA, Gene Panel, IRB, Lines of treatment, Mutation Rate, Oncotree Code, PD-L1 Score (%), Smoker,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Large Cell
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    Lung Neoplasms
    Access Rights
    Free to All
  • Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [EPIC]

    Authors
    Quintanal Villalonga, Alvaro Diego
    Zhan, Yingqian
    Rudin, Charles M.
    Description

    Summary from GEO: "To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation." Overall design from GEO: "We performed EPIC (methyl-capture) in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas."

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Squamous Cell
    Methylation
    Access Rights
    Free to All
  • Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [RNA-seq]

    Authors
    Quintanal Villalonga, Alvaro Diego
    Zhan, Yingqian
    Rudin, Charles M.
    Description

    Summary from GEO: "To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation." Overall design from GEO: "We performed RNAseq in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas."

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Squamous Cell
    RNA-Seq
    Access Rights
    Free to All
  • Next Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases

    Authors
    Paik, Paul K.
    Description

    Description from dbGaP: "Putative oncogenic pathways in squamous cell lung cancer have been recently characterized, although their biologic repercussions in patients is largely unknown. This study sought to discover potential clinical manifestations of major pathways in squamous cell lung cancer, particularly the PI3K pathway. Two key findings emerged: patients with stage IV squamous cell lung cancer...

    Subject
    Brain Neoplasms
    Carcinoma, Squamous Cell
    Lung Neoplasms
    Neoplasm Metastasis
    RNA-Seq
    Whole Genome Sequencing
    Access Rights
    Application Required