-
Myelodysplastic (MSKCC, 2020): Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms
- Description
This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.
- Subject
-
Acute monoblastic/monocytic leukemiaAnemia, RefractoryAnemia, Refractory, with Excess of BlastsAnemia, SideroblasticLeukemia, Erythroblastic, AcuteLeukemia, Megakaryoblastic, AcuteLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLeukemia, Myelomonocytic, AcuteLeukemia, Myelomonocytic, ChronicMastocytosisMyelodysplastic SyndromesMyelodysplastic-Myeloproliferative DiseasesOncogene Proteins, FusionPolycythemia VeraPrimary MyelofibrosisSarcoma, MyeloidThrombocythemia, Essential
- Access Rights
- Free to All
- Local Expert
- Papaemmanuil, Elli
-
CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [ATAC-Seq]
- Authors
- Dunbar, AndrewHoffman, RonaldKoche, Richard PatrickLevine, Ross L.
- Description
Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...
- Subject
-
Chromatin Immunoprecipitation SequencingInterleukin-8Myeloproliferative DisordersPrimary MyelofibrosisReceptors, Interleukin-8B
- Access Rights
- Free to All
-
CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [RNA-Seq]
- Authors
- Dunbar, AndrewKoche, Richard PatrickLevine, Ross L.Hoffman, Ronald
- Description
Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...
- Subject
-
Interleukin-8Myeloproliferative DisordersPrimary MyelofibrosisReceptors, Interleukin-8BRNA-Seq
- Access Rights
- Free to All