-
TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...
- Subject
-
DNA Mutational AnalysisImmunotherapyMutationTumor Burden
- Access Rights
-
Free to All
-
Single cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases
- Authors
-
Smalley, InnaChen, ZhihuaSmalley, Kieran S. M.Chen, Y. Ann
- Description
Summary from GEO: "Melanoma brain metastases (MBM) and leptomeningeal metastases (LMM) are two manifestations of melanoma CNS metastasis with vastly different survival outcomes. Using single cell RNA-Seq analysis we uncovered a unique, immune-suppressed T-cell landscape in the LMM microenvironment distinct from that of brain and skin metastases. An LMM patient with an unusually long survival demonstrated...
- Subject
-
Brain NeoplasmsMeningeal NeoplasmsRNA-SeqSingle-Cell Gene Expression AnalysisT-LymphocytesTumor Microenvironment
- Access Rights
-
Free to All