This dataset contains summary data visualizations and clinical data from a broad sampling of 494 prostate adenocarcinomas from 494 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

This dataset contains summary data visualizations and clinical data from a broad sampling of 504 prostate tumor samples from 451 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient age, Clinical Gleason, Clinical...

This dataset contains summary data visualizations and clinical data from a broad sampling of prostate adenocarcinomas. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics, tumor sample details, Impact TMB Score,...

TCGA Prostate Adenocarcinoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 501 carcinomas from 500 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

This dataset contains summary data visualizations and clinical data from a broad sampling of 334 prostate adenocarcinomas from 334 patients. The clinical data includes mutation count, information about mutated genes, patient demographics, tumor sample details, Subtype, Absolute Extract Ploidy, Absolute Extract Purity, Absolute Genome Doublings, AKT1 Mutation , AR mRNA, AR Protein, AR Score, AR V7...

This dataset contains the summary data visualizations and clinical data of IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal from 118 patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Sex, Primary/Metastasis Sample Type, Collaboration Id, Gene Panel, Oncotree Code, Tumor/cfDNA Sample...

This dataset contains the summary data visualizations and clinical data of the Whole exome Sequencing of 1,013 prostate cancer samples and their matched normals for 1,013 patients. Clinical data includes: Mutation Count, Fraction Genome Altered, Diagnosis Age, Primary/ Metastasis Sample Type, Data Source, Fusion, Metastatic Site, Mutation Burden, Normal Genome Coverage, Ploidy, Purity, Radical Prostatectomy...

Expression profiling by high throughput sequencing Methylation profiling by high throughput sequencing Summary: This SuperSeries is composed of the following SubSeries: GSE112786: "Molecular characterization of neuroendocrine prostate cancer organoids and PDOX by RNA-seq GSE112829: Methylation profile of neuroendocrine prostate cancer models. Both of the SubSeries concerns information neuroendocrine...

Summary from GEO: "The inherent plasticity of tumor cells provides a mechanism of resistance to many molecularly targeted therapies, exemplified by adeno-to-neuroendocrine lineage transitions seen in prostate and lung cancer. Here we investigate the root cause of this lineage plasticity in a primary murine prostate organoid model that mirrors the lineage transition seen in patients. These cells lose...

Summary from GEO: "In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 in NE transformation. We observed upregulated exportin 1 in lung and prostate pre-transformation...