This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...

Summary from GEO: "To investigate the effects of loss of LSD1 (KDM1A) on differential gene expression, we treated two cell lines of small cell lung cancer with 1uM LSD1 inhibitor ORY-1001 or vehicle control for 10 days. We then performed gene expression profiling analysis on treated and control cells for each of the two cell lines." Overall design from GEO: "Comparative gene expression profiling...

Description from Figshare: "Supplementary Figure 1: Example of KRAS-mutated LCNEC: Illustration of NGS and histopathologic features; Supplementary Figure 2: Dot plots for total number of genomic alterations in carcinoid-like vs other LCNECs; Supplementary Figure 3: OncoPrints for chromatin modifier, neurogenesis/neural function, DNA replication/repair and PI3K-AKT-mTOR pathway genes; Supplementary...

Description from Figshare: "Supplementary Table 1: Next-generation sequencing (MSK-IMPACT) gene panel"

Description from Figshare: "Supplementary Table 2: Immunohistochemical antibodies and protocols"

Description from Figshare: "Supplementary Table 4: Complete list of mutations and copy number alterations detected by MSK-IMPACT in 45 LCNECs"

Description from Figshare: "Supplementary Table 5: Detailed summary of NOTCH gene family mutations"

Description from Figshare: "Supplementary Table 6: Complete list of potentially-actionable alterations"

Description from Figshare: "Supplementary Table 7: Detailed chemosensitivity data"

Description from Figshare: "Supplementary Table 3: Clinicopathologic characteristics"