Summary from the GEO: "Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a core nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The corresponding controversy about whether UPF1 mutations are important contributors...

Description from the BioProject: "In this study, whole genome sequencing and whole exome sequencing were performed to detect the genomic features of the pancreatic adenosquamous carcinoma." 125 samples were deposited and sequenced in this submission.

This dataset contains summary data visualizations and clinical data from targeted sequencing of 25040 tumors from 24950 patients and their matched normals via MSK-IMPACT, along with clinical annotations, some of which are derived from natural language processing (denoted NLP). This data is available under the Creative Commons BY-NC-ND 4.0 license. For commercial use, please contact datarequests@mskcc.org....