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Results Found: 11
  • Clinical Proteomic Tumor Analysis Consortium Data

    Alternate Title(s)
    CPTAC
    Description

    The Clinical Proteomic Tumor Analysis Consortium (CPTAC) analyzes cancer biospecimens by mass spectrometry, characterizing and quantifying their constituent proteins, or proteome. Proteomic analysis for each CPTAC study is carried out independently by Proteomic Characterization Centers (PCCs) using a variety of protein fractionation techniques, instrumentation, and workflows. Mass spectrometry and...

    Subject
    Chemical fractionation
    Genomics
    Mass spectrometry
    Proteome
    Access Rights
    Free to All
  • Glioblastoma Multiforme (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 592 glioblastoma multiformes from 585 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

    Subject
    DNA Mutational Analysis
    Glioblastoma
    Access Rights
    Free to All
  • Glioma (MSKCC, Clin Cancer Res 2019): Targeted sequencing on MSK-IMPACT and FMI Panels of 1004 samples (837 with matched normals) from 923 glioma patients.

    Description

    This dataset contains summary data visualizations and clinical data from 1,004 samples of glioma tumors from 924 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics, disease status, and sample details....

    Subject
    Brain Neoplasms
    DNA Mutational Analysis
    Access Rights
    Free to All
  • TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...

    Subject
    DNA Mutational Analysis
    Immunotherapy
    Mutation
    Tumor Burden
    Access Rights
    Free to All
  • Tumors with TRK fusions (MSK, 2019): Tumors with TRK fusions based on MSK-IMPACT targeted sequencing.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of tropomyosin receptor kinase (TRK) fusion tumors. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), information about mutated genes, patient demographics, and modality. The data set also...

    Subject
    DNA Mutational Analysis
    Oncogene Proteins, Fusion
    Receptor Protein-Tyrosine Kinases
    Receptor, trkA
    Receptor, trkB
    Receptor, trkC
    Access Rights
    Free to All
  • Glioblastoma Multiforme (TCGA, Firehose Legacy)

    Description

    TCGA Glioblastoma Multiforme. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 619 glioblastoma multiformes from 606 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count,...

    Subject
    DNA Mutational Analysis
    Glioblastoma
    Access Rights
    Free to All
  • Characterization of tumor initiating cells from human glioblastoma multiforms by scRNA seq

    Authors
    Wang, Rong
    Sharma, Roshan
    Laughney, Ashley Marie
    Masilionis, Ignas
    2 more author(s)...
    Description

    Summary from the GEO: Radial Glia (RG) cells are the first neural stem cells to appear during embryonic development. Human embryonic RG cells demonstrates a specific set of gene expression compared to other type of progenitor cells. The goal of this study is to characterize the potential origine of tumor initiating cells of human glioblastoma multiforms by single cell RNASeq analyses of freshly sorted...

    Subject
    Brain Neoplasms
    Ependymoglial Cells
    Glioblastoma
    Access Rights
    Free to All
  • Glioma (MSK, Nature 2019): Targeted Sequencing of CSF samples (91 samples with 86 matched normals) from 42 glioma patients

    Description

    This dataset contains the summary data visualizations and clinical data from the targed sequencing of 91 CSF samples from 42 glioma patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered Sample Type, Sex, Oncotree Code, Sample Collection Method, Somatic Status, Specimen Preservation Type. The plaintext components of the dataset can be...

    Subject
    Astrocytoma
    Glioblastoma
    Glioma
    Gliosarcoma
    Oligodendroglioma
    Access Rights
    Free to All
  • Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

    Authors
    Amoozgar, Zohreh
    Kloepper, Jonas
    Ren, Jun
    Tay, Rong E.
    18 more author(s)...
    Description

    Summary from the GEO: "Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas. Targeting glucocorticoid-induced TNFR-related receptor (GITR) in Treg cells using an agonistic antibody (αGITR) promotes CD4 Treg cell differentiation into CD4 effector T cells,...

    Subject
    Glioblastoma
    Immune Checkpoint Inhibitors
    T-Lymphocytes, Regulatory
    Access Rights
    Free to All
  • Microenvironment-driven IGF-1R/PI3K signaling underlies acquired resistance to CSF1R inhibition in gliomas (CGH)

    Authors
    Bowman, Robert L.
    Quail, Daniela F.
    Schuhmacher, Alberto J.
    Joyce, Johanna A.
    Description

    Summary form GEO: "Macrophages accumulate with glioblastoma multiforme (GBM) progression, and can be acutely targeted via inhibition of colony stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models. However, whether and how resistance emerges in response to sustained CSF-1R blockade is unknown. Here, we investigate whether long-term CSF-1R inhibition can stably regress...

    Subject
    Drug Therapy, Combination
    Glioblastoma
    Macrophages
    Neoplasm Recurrence, Local
    Phosphoinositide-3 Kinase Inhibitors
    Receptor, IGF Type 1
    Tumor Microenvironment
    Access Rights
    Free to All