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  • TMB and Immunotherapy (MSKCC, Nat Genet 2019): Genomic and survival data from 1661 tumor-normal pairs from 1661 patients with various cancer types sequenced with the MSK-IMPACT assay.

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 1,661 samples of across multiple cancer types showing tumor mutational load and survival following immunotherapy from 1,661 patients. The data was gathered utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK),...

    Subject
    DNA Mutational Analysis
    Immunotherapy
    Mutation
    Tumor Burden
    Access Rights
    Free to All
  • SUMMIT - Neratinib Basket Study (Multi-Institute, Nature 2018): MSK-IMPACT sequencing of 86 patients with HER2- and HER3-mutant cancers

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of HER2- and HER3-mutant tumors. The data was generated utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, Amplification Status, Best objective response rate, Bubble...

    Subject
    Breast Neoplasms
    Carcinoma, Hepatocellular
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Renal Cell
    Colorectal Neoplasms
    DNA Mutational Analysis
    Endometrial Neoplasms
    Esophageal Neoplasms
    Genes, erbB
    Genes, erbB-2
    Melanoma
    Ovarian Neoplasms
    Pancreatic Neoplasms
    Salivary Gland Neoplasms
    Sarcoma
    Skin Neoplasms
    Urinary Bladder Neoplasms
    Uterine Cervical Neoplasms
    Access Rights
    Free to All
  • Thoracic PDX (MSK, Provisional): Targeted sequencing of thoracic PDX lines to characterize genetic alterations in 139 tumor/normal pairs via MSK-IMPACT.

    Description

    This dataset contains summary data visualizations and clinical data from a broad 183 samples of thoracic tumors from 77 patients. The data was generated by the Charles Rudin Lab, utilizing the MSK-IMPACT targeted sequencing test. The clinical data includes tumor type (based on the opensource OncoTree ontology developed at MSK), mutation count, information about mutated genes, patient demographics,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Non-Small-Cell Lung
    DNA Mutational Analysis
    Lung Neoplasms
    Mesothelioma
    Access Rights
    Free to All
  • Non-Small Cell Lung Cancer (MSKCC, J Clin Oncol 2018): IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy.

    Description

    This dataset contains the summary data visualizations and clinical data from IMPACT sequencing of 240 NSCLC tumor/normal pairs treated at MSKCC with anti-PD-(L)1 based therapy from 240 patients. Clinical data includes: Cancer Type, Mutation Count, Fraction Genome Altered, Sex, Durable Clinical Benefit, FGA, Gene Panel, IRB, Lines of treatment, Mutation Rate, Oncotree Code, PD-L1 Score (%), Smoker,...

    Subject
    Adenocarcinoma of Lung
    Carcinoma, Large Cell
    Carcinoma, Non-Small-Cell Lung
    Carcinoma, Squamous Cell
    Lung Neoplasms
    Access Rights
    Free to All
  • Supplementary Figures 1-6 from Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets

    Authors
    Rekhtman, Natasha
    Pietanza, Maria C.
    Hellmann, Matthew D.
    Naidoo, Jarushka
    16 more author(s)...
    Description

    Description from Figshare: "Supplementary Figure 1: Example of KRAS-mutated LCNEC: Illustration of NGS and histopathologic features; Supplementary Figure 2: Dot plots for total number of genomic alterations in carcinoid-like vs other LCNECs; Supplementary Figure 3: OncoPrints for chromatin modifier, neurogenesis/neural function, DNA replication/repair and PI3K-AKT-mTOR pathway genes; Supplementary...

    Subject
    Carcinoma, Neuroendocrine
    Carcinoma, Non-Small-Cell Lung
    DNA Replication
    Genes, ras
    Genomics
    Lung Neoplasms
    Small Cell Lung Carcinoma
    Access Rights
    Free to All
  • MSK-CHORD (MSK, Nature 2024)

    Description

    This dataset contains summary data visualizations and clinical data from targeted sequencing of 25040 tumors from 24950 patients and their matched normals via MSK-IMPACT, along with clinical annotations, some of which are derived from natural language processing (denoted NLP). This data is available under the Creative Commons BY-NC-ND 4.0 license. For commercial use, please contact datarequests@mskcc.org....

    Subject
    Clinical Trial
    Data Visualization
    Machine Learning
    Sequence Analysis
    Access Rights
    Free to All