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Myelodysplastic (MSKCC, 2020): Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms
- Description
This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.
- Subject
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Acute monoblastic/monocytic leukemiaAnemia, RefractoryAnemia, Refractory, with Excess of BlastsAnemia, SideroblasticLeukemia, Erythroblastic, AcuteLeukemia, Megakaryoblastic, AcuteLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLeukemia, Myelomonocytic, AcuteLeukemia, Myelomonocytic, ChronicMastocytosisMyelodysplastic SyndromesMyelodysplastic-Myeloproliferative DiseasesOncogene Proteins, FusionPolycythemia VeraPrimary MyelofibrosisSarcoma, MyeloidThrombocythemia, Essential
- Access Rights
- Free to All
- Local Expert
- Papaemmanuil, Elli
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [Celline_scATAC]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
- Subject
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Anemia, SideroblasticBinding sitesFibroblastsGenomicsHeteroplasmy/geneticsMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scRNA]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
- Subject
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Anemia, SideroblasticGene Expression ProfilingGenomicsHeteroplasmy/geneticsLeukocytes, MononuclearMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All
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Cellular states, clonal dynamics, and evolution in Pearson syndrome revealed via single-cell multi-omics [PBMC_scATAC]
- Authors
- Lareau, Caleb A.Ludwig, Leif S.
- Description
Summary from GEO: "Large deletions in mitochondrial DNA (mtDNA) have been linked to a variety of clinical pathologies, including somatic emergence in congenital disorders such as Pearson Syndrome (MIM:557000), a mitochondrial disease characterized by sideroblastic anemia and exocrine pancreas dysfunction. Here, we develop a multi-omics approach to quantify mtDNA deletion heteroplasmy and cell state...
- Subject
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Anemia, SideroblasticBinding sitesGenomicsHeteroplasmy/geneticsLeukocytes, MononuclearMyelodysplastic SyndromesSingle-Cell Analysis
- Access Rights
- Free to All