An Informatic Approach to Chimeric Antigen Receptor Discovery Integrates Proteomics and Transcriptomics to Identify Novel Combinatorial Pairs

Authors

Berman, Samuel Hart

Sadelain, Michel W. J.

Description

Chimeric antigen receptor (CAR) therapy targeting CD19 yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for over-expressed molecules with potentially tolerable systemic expression. We integrated large transcriptomics and proteomics data sets from malignant and normal tissues, and...

Subject

Antigens, CD19

Leukemia, Myeloid, Acute

Proteomics

Receptors, Chimeric Antigen

Transcriptome

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