Summary from GEO: "In vitro cultured CD34+ derived erythroblasts were sorted using surface markers and processed using RNA-seq." Overall design "Biological replicates (3 or 4 per population) were processed across 2-3 biological donors for 8 sorted populations for RNA-seq."

Summary from GEO: "In vitro cultured CD34+ derived erythroblasts were sorted using surface markers and processed using ATAC-seq." Overall design from GEO: "Biological replicates (3 or 4 per population) were processed across 2-3 biological donors for 8 sorted populations for ATAC-seq."

Description from EMBL-EBI: "We investigated whether GATA2 enhancer-driven transcription of EVI1 in inv(3)/t(3;3) is reversible in leukemia cells. In primary inv(3)/t(3;3) AML, immature CD34+CD15- cells can be discriminated from more mature CD34-CD15- and CD34-CD15+ cells. Besides, we also investigated the effect of deleting a MYB binding site on these cells using CRISPR/Cas9." Detailed sample and...