Description from BioProject: "In this study, we ablated, individually and in combination, Brca1, Brca2 and Palb2 along with one copy of Trp53 in the mouse mammary gland. We also studied spontaneous tumor development in Palb2 mutant mice with a mutation that disengages the BRCA1-PALB2 interaction, in Trp53 wt, heterozygous and homozygous null backgrounds. Whole exome sequencing was conducted for 35...

Study Description from dbGaP: "The data come from 40 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). CIMBA recruits individuals with pathogenic mutations in BRCA1 or BRCA2. The majority of carriers were recruited through cancer genetics clinics offering genetic testing, and were enrolled into national or regional studies. The remainder were identified by population-based...