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The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma
- Authors
- Polaski, Jacob T.Kannan, RamBradley, Robert K.
- Description
Summary from the GEO: "Pancreatic adenosquamous carcinoma (PASC) is an aggressive cancer whose mutational origins are poorly understood. An early study reported high-frequency somatic mutations affecting UPF1, a core nonsense-mediated mRNA decay (NMD) factor, in PASC, but subsequent studies did not observe these lesions. The corresponding controversy about whether UPF1 mutations are important contributors...
- Subject
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Carcinoma, AdenosquamousPancreatic NeoplasmsRNA HelicasesTrans-Activators
- Access Rights
- Free to All
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Pancreatic ductal adenocarcinoma and panreatic adenosquamous carcinoma sequencing
- Description
Description from the BioProject: "In this study, whole genome sequencing and whole exome sequencing were performed to detect the genomic features of the pancreatic adenosquamous carcinoma." 125 samples were deposited and sequenced in this submission.
- Subject
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Carcinoma, AdenosquamousPancreatic Neoplasms
- Access Rights
- Free to All