Summary from GEO: "Acute myelogenous leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted therapies is critical to improving outcomes. Importantly, how to target loss-of-function mutations has been a critical challenge in precision...

Summary from the GEO: "Acute myelogenous leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted therapies is critical to improving outcomes. Importantly, how to target loss-of-function mutations has been a critical challenge in precision...

This Dataset is a SuperSeries composed of the following SubSeries: GSE140359 DOT1L inhibitors block abnormal self-renewal induced by cohesin loss [RNA-seq] GSE140360 DOT1L inhibitors block abnormal self-renewal induced by cohesin loss [ChIP-seq] Data stored in this GEO relates to Acute myeloid leukemia (AML) and DOT1L inhibitors stored in two sequence formats.

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the structure of human SHLD2-SHLD3-REV7-TRIP13(E253Q) complex. The main summary display for this entry includes information on the experimental method, validation, macromolecules and small molecules in the deposit, as well as entry history. Data...