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  • Mixed cfDNA (MSKCC, 2020): IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal

    Description

    This dataset contains the summary data visualizations and clinical data of IMPACT sequencing of 229 cell-free DNA (cfDNA) and associated tumor samples with matched normal from 118 patients. Clinical data includes: Cancer Type, Number of Samples Per Patient, Mutation Count, Fraction Genome Altered, Sex, Primary/Metastasis Sample Type, Collaboration Id, Gene Panel, Oncotree Code, Tumor/cfDNA Sample...

    Subject
    Adenocarcinoma
    Adenocarcinoma of Lung
    Breast Neoplasms
    Carcinoma, Ductal, Breast
    Carcinoma, Neuroendocrine
    Carcinoma, Renal Cell
    Carcinoma, Squamous Cell
    Cell-Free Nucleic Acids
    Choriocarcinoma
    Endodermal Sinus Tumor
    Melanoma
    Neoplasms, Germ Cell and Embryonal
    Neoplasms, Squamous Cell
    Neuroendocrine Tumors
    Prostatic Neoplasms
    Seminoma
    Small Cell Lung Carcinoma
    Urinary Bladder Neoplasms
    Access Rights
    Free to All
  • Mixed cfDNA (MSK, Nature Medicine 2019): Targeted sequencing of 248 samples from 124 patients' cfDNA/WBC and tumor/normal pairs.

    Description

    This dataset contains the summary data visualizations and clinical data of targeted sequencing of 248 samples from 124 patients' cfDNA/WBC[White Blood Cell] and tumor/normal pairs. Clinical data includes: Cancer Type, Mutation Count, Age, Tumor Type, cfDNA TMB, Collapsed fragment mean coverage, Collapsed mean coverage, ctDNA Fraction, MSI Score, Oncotree Code, cfDNA/Tumor Sample Class, Tumor Tissue...

    Subject
    Breast Neoplasms
    Carcinoma, Non-Small-Cell Lung
    Cell-Free Nucleic Acids
    Prostatic Neoplasms
    Access Rights
    Free to All
  • Tumor Fraction Guided Cell-Free DNA Profiling in Metastatic Cancer Patients

    Authors
    Solit, David
    Tsui, Wai Yi
    Description

    Study Description from daGaP: "Cell-free DNA (cfDNA) profiling is increasingly used to guide cancer care, yet mutations are not always identified. The ability to detect somatic mutations in plasma depends on both assay sensitivity and the fraction of circulating DNA in plasma that is tumor-derived (i.e cfDNA tumor fraction). We hypothesized that cfDNA tumor fraction could inform the interpretation...

    Subject
    Cell-Free Nucleic Acids
    DNA Mutational Analysis
    Access Rights
    Application Required