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DNA damage-induced transcriptome changes in budding yeasts Saccharomyces cerevisiae and Candida glabrata
- Authors
- Shor, ErikaPerlin, David S.
- Description
Summary from the GEO: "This study compared the transcriptional response to DNA damage in two closely related yeasts, S. cerevisiae and C. glabrata." Overall design from the GEO: "We cultured S. cerevisiae and C. glabrata in YPD containing 0.1% methyl methanesulfonate (MMS) for 1 hour, harvested the cells, isolated total RNA using the Qiagen Rneasy kit, and sent the RNA to Genewiz for RNAseq. Untreated...
- Subject
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Checkpoint Kinase 2DNA DamageProliferating Cell Nuclear Antigen
- Access Rights
- Free to All
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ISG15 Conjugation to Proteins on Nascent DNA Mitigates DNA Replication Stress
- Authors
- Li, ZhuoningPetrini, John
- Description
Description from PRIDE: "The pathways involved in suppressing DNA replication stress and the associated DNA damage are critical to maintaining genome integrity. The Mre11 complex is unique among double strand break (DSB) repair proteins for its association with the DNA replication fork. Here we show that Mre11 complex inactivation causes DNA replication stress and changes in the abundance of proteins...
- Subject
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DNA Breaks, Double-StrandedDNA DamageDNA RepairDNA ReplicationMRE11 Homologue Protein
- Access Rights
- Free to All
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The mutational characterization of adenoid cystic carcinoma
- Authors
- Chan, Timothy A.
- Description
Description from dbGaP: "Adenoid cystic carcinoma (ACC) typically emanate from the major and minor salivary glands of the head and neck. ACCs have high rates of perineural invasion, locoregional recurrence, and distant metastasis. Here we report sequencing of 60 tumor/normal pairs and find substantial mutational diversity. On pathway analysis, a significant percentage of mutations involved chromatin...
- Subject
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Carcinoma, Adenoid CysticDNA DamageMutationSalivary Gland NeoplasmsWhole Genome Sequencing
- Access Rights
- Application Required