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Results Found: 3
  • DNA damage-induced transcriptome changes in budding yeasts Saccharomyces cerevisiae and Candida glabrata

    Authors
    Shor, Erika
    Perlin, David S.
    Description

    Summary from the GEO: "This study compared the transcriptional response to DNA damage in two closely related yeasts, S. cerevisiae and C. glabrata." Overall design from the GEO: "We cultured S. cerevisiae and C. glabrata in YPD containing 0.1% methyl methanesulfonate (MMS) for 1 hour, harvested the cells, isolated total RNA using the Qiagen Rneasy kit, and sent the RNA to Genewiz for RNAseq. Untreated...

    Subject
    Checkpoint Kinase 2
    DNA Damage
    Proliferating Cell Nuclear Antigen
    Access Rights
    Free to All
  • ISG15 Conjugation to Proteins on Nascent DNA Mitigates DNA Replication Stress

    Authors
    Li, Zhuoning
    Petrini, John
    Description

    Description from PRIDE: "The pathways involved in suppressing DNA replication stress and the associated DNA damage are critical to maintaining genome integrity. The Mre11 complex is unique among double strand break (DSB) repair proteins for its association with the DNA replication fork. Here we show that Mre11 complex inactivation causes DNA replication stress and changes in the abundance of proteins...

    Subject
    DNA Breaks, Double-Stranded
    DNA Damage
    DNA Repair
    DNA Replication
    MRE11 Homologue Protein
    Access Rights
    Free to All
  • The mutational characterization of adenoid cystic carcinoma

    Authors
    Chan, Timothy A.
    Description

    Description from dbGaP: "Adenoid cystic carcinoma (ACC) typically emanate from the major and minor salivary glands of the head and neck. ACCs have high rates of perineural invasion, locoregional recurrence, and distant metastasis. Here we report sequencing of 60 tumor/normal pairs and find substantial mutational diversity. On pathway analysis, a significant percentage of mutations involved chromatin...

    Subject
    Carcinoma, Adenoid Cystic
    DNA Damage
    Mutation
    Salivary Gland Neoplasms
    Whole Genome Sequencing
    Access Rights
    Application Required