Intrinsic Coupling of Lagging Strand Synthesis to Chromatin Assembly

Authors

Smith, Duncan J.

McGuffee, S.

Whitehouse, Iestyn

Description

Summary from GEO: "We show that ligation-competent Okazaki fragments in Saccharomyces cerevisiae are sized according to the chromatin repeat. Using deep sequencing, we demonstrate that ligation junctions preferentially occur around nucleosome midpoints rather than in internucleosomal linker regions. Disrupting chromatin assembly or lagging strand polymerase processivity impacts both the size and...

Subject

Chromatin

Chromatin Assembly and Disassembly

DNA Ligases

DNA Replication

Gene Knockout Techniques

Nucleotides

Access Rights

Free to All