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Inter-myeloid cell synaptic antigen dispersal drives diversified anti-tumor T cell priming
- Authors
- Roberts, EdwardKrummel, Matthew F.
- Description
Summary from the GEO: "Using a labelled tumor antigen we identify dendritic cell subsets containing tumor derived antigen in the tumor draining lymph nodes and used these to stimulate anti-tumor OTI CD8 T cells. These were subsequently interrogated by RNAseq to determine how diverse DC subsets drive distinct patterns of CD8 T cell differentiation" Overall design from the GEO: "OTI CD8 T cell RNAseq...
- Subject
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Dendritic CellsT-Lymphocytes
- Access Rights
- Free to All
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RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
- Authors
- Berres, Marie-LuiseHogstad, BrandonChakraborty, RikhiaAllen, Carl E1 more author(s)...
- Description
Summary from GEO: " Expression data from dendritic cell subsets derived or sorted from control littermate and CD11c-Cre/BRAFV600E(flox-CA) mice Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with constitutively activated mitogen-activated protein kinase (MAPK) pathway signaling. Approximately...
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bcl-X ProteinDendritic CellsHistiocytosis, Langerhans-CellMitogen-Activated Protein Kinase KinasesProto-Oncogene Proteins B-rafReceptors, CCR7
- Access Rights
- Free to All
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Transcriptional basis of mouse and human dendritic cell heterogeneity revealed by single-cell profiling
- Authors
- Brown, Chrysothemis C.Gudjonson, HermanPritykin, YuryDeep, Deeksha8 more author(s)...
- Description
Summary from GEO: "Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to their unique ability to serve as a principal antigen-presenting cell type capable of initiating T cell responses. Classical dendritic cells have been divided into two subsets, cDC1 and cDC2, based on phenotypic markers and their distinct abilities to prime CD8 and CD4 T cells and direct...
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CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDendritic CellsMelanomaRNA-SeqSingle-Cell Analysis
- Access Rights
- Free to All
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A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [multiome scATAC-seq]
- Authors
- Brown, Chrysothemis C.Tayyebi, Zakieh
- Description
Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...
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Chromatin Immunoprecipitation SequencingDendritic CellsEpithelial CellsNuclear Receptor Subfamily 1, Group F, Member 3Single-Cell Gene Expression AnalysisT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [Smart-seq2]
- Authors
- Brown, Chrysothemis C.Rudensky, Alexander Y.Tayyebi, ZakiehLeslie, Christina
- Description
Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...
- Subject
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Dendritic CellsEpithelial CellsNuclear Receptor Subfamily 1, Group F, Member 3Single-Cell AnalysisT-Lymphocytes, Regulatory
- Access Rights
- Free to All
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A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [multiome scRNA-seq]
- Authors
- Brown, Chrysothemis C.Tayyebi, Zakieh
- Description
Summary from GEO: "Tolerance to self- or innocuous foreign antigens is vital for preservation of organismal health. Within the thymus, medullary thymic epithelial cells (mTECs) expressing AutoImmune Regulator, Aire, play a critical role in self-tolerance through deletion of autoreactive T cells and promotion of thymic regulatory T (Treg) cell development. A second wave of Treg cell differentiation...
- Subject
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Chromatin Immunoprecipitation SequencingDendritic CellsEpithelial CellsNuclear Receptor Subfamily 1, Group F, Member 3Single-Cell Gene Expression AnalysisT-Lymphocytes, Regulatory
- Access Rights
- Free to All
