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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- Authors
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Chan, Timothy A.Baylin, Stephen B.Wolchok, Jedd D.Chiapinelli, Katherine B.1 more author(s)...
- Description
Description from dbGaP: "We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway and re-expression of epigenetically silenced endogenous retrovirus. In melanoma patients treated with an immune checkpoint therapy, high viral defense signature expression in tumors significantly associates with durable clinical response and DNMTi...
- Subject
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DNA MethylationEndogenous RetrovirusesImmunotherapyMelanoma
- Access Rights
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Application Required