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Sarcoma (TCGA, PanCancer Atlas)
- Description
This dataset contains summary data visualizations and clinical data from a broad sampling of 255 sarcomas from 255 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information about mutated genes,...
- Subject
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DNA Mutational AnalysisFibromatosis, AggressiveFibrosarcomaHistiocytoma, Malignant FibrousLeiomyosarcomaLiposarcomaNerve Sheath NeoplasmsNeurofibromaSarcomaSarcoma, Synovial
- Access Rights
- Free to All
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Sarcoma (TCGA, Firehose Legacy)
- Description
TCGA Sarcoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 200 carcinomas from 200 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information about mutated...
- Subject
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DNA Mutational AnalysisFibromatosis, AggressiveFibrosarcomaHistiocytoma, Malignant FibrousLeiomyosarcomaLiposarcomaNerve Sheath NeoplasmsNeurofibromaSarcomaSarcoma, Synovial
- Access Rights
- Free to All
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Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma
- Authors
- Lee, Ann Y.Okada, TomoyoAgaram, NarasimhanQin, Li-Xuan11 more author(s)...
- Description
Summary from GEO: "Analysis of U133A microarray data from 64 primary high-grade tumors identified ITGA10 as the gene most significantly associated with distant metastasis and poor disease-specific survival. Further investigation using shRNA knockdown identifies the TRIO-RAC-PAK and RICTOR-mTORC2 pathways as important downstream signaling pathways for ITGA10." Overall design from GEO: "RNA samples...
- Subject
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FibrosarcomaIntegrin alpha ChainsNeoplasm MetastasisSurvival Analysis
- Access Rights
- Free to All