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  • Sarcoma (TCGA, PanCancer Atlas)

    Description

    This dataset contains summary data visualizations and clinical data from a broad sampling of 255 sarcomas from 255 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information about mutated genes,...

    Subject
    DNA Mutational Analysis
    Fibromatosis, Aggressive
    Fibrosarcoma
    Histiocytoma, Malignant Fibrous
    Leiomyosarcoma
    Liposarcoma
    Nerve Sheath Neoplasms
    Neurofibroma
    Sarcoma
    Sarcoma, Synovial
    Access Rights
    Free to All
  • Sarcoma (TCGA, Firehose Legacy)

    Description

    TCGA Sarcoma. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 200 carcinomas from 200 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information about mutated...

    Subject
    DNA Mutational Analysis
    Fibromatosis, Aggressive
    Fibrosarcoma
    Histiocytoma, Malignant Fibrous
    Leiomyosarcoma
    Liposarcoma
    Nerve Sheath Neoplasms
    Neurofibroma
    Sarcoma
    Sarcoma, Synovial
    Access Rights
    Free to All
  • Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma

    Authors
    Lee, Ann Y.
    Okada, Tomoyo
    Agaram, Narasimhan
    Qin, Li-Xuan
    11 more author(s)...
    Description

    Summary from GEO: "Analysis of U133A microarray data from 64 primary high-grade tumors identified ITGA10 as the gene most significantly associated with distant metastasis and poor disease-specific survival. Further investigation using shRNA knockdown identifies the TRIO-RAC-PAK and RICTOR-mTORC2 pathways as important downstream signaling pathways for ITGA10." Overall design from GEO: "RNA samples...

    Subject
    Fibrosarcoma
    Integrin alpha Chains
    Neoplasm Metastasis
    Survival Analysis
    Access Rights
    Free to All