Description from BioProject: "In this study, we ablated, individually and in combination, Brca1, Brca2 and Palb2 along with one copy of Trp53 in the mouse mammary gland. We also studied spontaneous tumor development in Palb2 mutant mice with a mutation that disengages the BRCA1-PALB2 interaction, in Trp53 wt, heterozygous and homozygous null backgrounds. Whole exome sequencing was conducted for 35...

Figshare Summary: "This metadata record provides details of the data supporting the claims of the related article: “Genetic interactions among Brca1, Brca2, Palb2 and Trp53 in mammary tumor development”. The related study conducted parallel conditional knockout (CKO) of Brca1, Palb2 and Brca2, individually and in combination, along with one copy of Trp53, in the mammary gland of nulliparous female...

Summary from GEO: "Human prostate cancer LNCaP cells infected with Lentivirus carried huamn BRCA2 gRNA alone or in combination with lentivirus carrying human RB1 shRNA. Infected cell were selcted by drug selection and the knockdown were confirm by westernblot or qPCR." Overall design from GEO: "To understand the role of co-loss of BRCA2 and RB1 in Human prostate cancer cells. RNA sequencing were...