Quiescent human glioblastoma cancer stem cells mediate tumor initiation, expansion, and recurrence following chemotherapy

Authors

Xie, Xuanhua P.

Laks, Dan R.

Ganbold, Mungunsarnai

Parada, Luis F.

Description

Summary from GEO: "We performed single cell RNA sequencing with eight patient derived xenograft samples to identify quiescent cancer stem cells in glioblastoma. Additionally two samples treated with temozolomide was sequenced to examine the evolution of the cancer stem cells upon chemotherapeutics." Overall design from GEO: "Whole transcriptome single cell RNA sequencing with 10X method."

Subject

Glioblastoma

Glioblastoma/drug therapy

Heterografts

Neoplastic Stem Cells

Single-Cell Gene Expression Analysis

Transcriptome

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