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Results Found: 5
  • Genetic analysis of HLA and immune escape genes in Diffuse Large B-cell Lymphoma

    Description

    Study Description from EGA: "Fifty percent of diffuse large B-cell lymphoma (DLBCL) cases lack cell-surface expression of the class-I major histocompatibility complex (MHC-I), thereby escaping immune recognition by cytotoxic T cells. In order to comprehensively identify the mechanisms involved in MHC-I loss, we first performed immunophenotypic analysis of both MHC class-I and -II in 657 cases across...

    Subject
    beta 2-Microglobulin
    Histocompatibility Antigens Class I
    HLA Antigens
    Lymphoma, Large B-Cell, Diffuse
    Access Rights
    Application Required
  • Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC ligands as Potential Targets for Cancer Immunotherapy

    Authors
    Klatt, Martin Gunther
    Scheinberg, David A.
    Description

    Description from PRIDE: "Cyclin dependent kinase 4/6 inhibitors (CDK4/6i) lead to cell-cycle arrest but also trigger T cell-mediated immunity, which might be mediated by the qualitative and quantitative changes in human leukocyte antigen (HLA) ligands on the cancer cell surface. We investigated the effects of CDK4/6i, Abemaciclib and Palbociclib, on the immunopeptidome at subclinical, non-toxic,...

    Subject
    Breast Neoplasms
    Cyclin-Dependent Kinase 4
    Cyclin-Dependent Kinase 6
    Cyclin-Dependent Kinase Inhibitor p16
    Cyclin-Dependent Kinase Inhibitor p18
    HLA Antigens
    T-Lymphocytes
    Access Rights
    Free to All
  • Single-cell RNA-seq datasets reprocessed using scHLApers pipeline

    Authors
    Kang, Joyce
    Description

    Description from Figshare: "Single-cell RNA-seq datasets reprocessed using scHLApers pipeline (Kang et al.)"

    Subject
    HLA Antigens
    RNA-Seq
    Single-Cell Gene Expression Analysis
    Access Rights
    Free to All
  • scHLApers

    Authors
    Kang, Joyce
    Description

    Description from Zenodo: "Code to run the scHLApers pipeline for personalized single-cell HLA quantification"

    Subject
    Electronic Data Processing
    HLA Antigens
    RNA-Seq
    Single-Cell Analysis
    Access Rights
    Free to All
  • hla2023

    Authors
    Kang, Joyce
    Description

    Description from GitHub and Zenodo: "Code for mapping single-cell eQTLs for HLA genes across four cohorts"

    Subject
    Genomics
    HLA Antigens
    Immunity, Active
    Quantitative Trait Loci
    Single-Cell Analysis
    Access Rights
    Free to All