Study Description from dbGaP: "Children with malignancies, immunodeficiencies, and other life-threatening diseases sometimes receive allogeneic hematopoietic cell transplantation (HCT) as a treatment for their disease. The HCT process can be complicated by the development of lung disease from infection, alloreactivity, or other causes. To identify patients at-risk for post-HCT lung disease, this...

Summary from Dryad: "Abstract: T cells are the central drivers of many inflammatory diseases, but the repertoire of tissue-resident T cells at sites of pathology in human organs remains poorly understood. We examined the site-specificity of T cell receptor (TCR) repertoires across tissues (5-18 tissues per patient) in prospectively collected autopsies of patients with and without graft-versus-host...

Summary from GEO: "Although allogeneic hematopoietic cell transplantation (allo-HCT) is curative for high-risk pediatric acute myeloid leukemia (AML), disease relapse remains the primary cause of post-transplant mortality. To identify pressures imposed by allo-HCT on AML cells that escape the graft-versus-leukemia effect, we evaluated immune signatures in bone marrow samples from four pediatric patients...

Description from Figshare: "Supplementary data files for a study investigating the associations between medication, microbiome and mortality in cancer patients." Abstract from Figshare: "Discerning the effect of pharmacological exposures on intestinal bacterial communities in cancer patients is challenging. Here, we deconvoluted the relationship between drug exposures and changes in microbial...

Description from GitHub: "This repository contains all the code and files needed for our scientific data project that highlights comparative and functional study using 395 shotgun metagenomic samples from hematopoietic cell transplant patients collected in the past 10 years in Memorial Hospital. We also demonstrate functional study of those data such as antibiotic resistance genes."