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  • Dnmt3a regulates myeloproliferation and liver-specific homing and expansion of hematopoietic stem and progenitor cells (Bisulfite-Seq)

    Authors
    Guryanova, Olga
    Spitzer, Barbara
    Garrett-Bakelman, Francine
    Levine, Ross L.
    Description

    Summary from GEO: "DNMT3A mutations are observed in myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Here we investigated the impact of conditional hematopoietic Dnmt3a loss on disease phenotype in primary mice. Dnmt3a ablation led to a lethal, fully penetrant myeloproliferative neoplasm with myelodysplasia (MDS/MPN)...

    Subject
    DNA Methyltransferase 3A
    Hematopoiesis
    Hepatomegaly
    Leukemia, Myeloid, Acute
    Myelodysplastic Syndromes
    Transcriptome
    Whole Genome Sequencing
    Access Rights
    Free to All

  • Dnmt3a regulates myeloproliferation and liver-specific homing and expansion of hematopoietic stem and progenitor cells (RNA-Seq)

    Authors
    Guryanova, Olga
    Spitzer, Barbara
    Rapaport, Franck Theoa
    Levine, Ross L.
    Description

    Summary from GEO: "DNMT3A mutations are observed in myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). Here we investigated the impact of conditional hematopoietic Dnmt3a loss on disease phenotype in primary mice. Dnmt3a ablation led to a lethal, fully penetrant myeloproliferative neoplasm with myelodysplasia (MDS/MPN)...

    Subject
    DNA Methyltransferase 3A
    Hematopoiesis
    Hepatomegaly
    Leukemia, Myeloid, Acute
    Myelodysplastic Syndromes
    RNA-Seq
    Transcriptome
    Access Rights
    Free to All