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Results Found: 4
  • A multivalent signal-transducing model for the DNMT1-mediated maintenance DNA methylation

    Authors
    Wang, Gang G.
    Grimm, Sara A.
    Description

    Summary from the GEO: "Heterochromatin-specific histone modifications frequently coexist with mammalian DNA methylation to orchestrate a repressive chromatin state. However, it remains elusive how these epigenetic modifications crosstalk. Here, we report that the first bromoadjacent homology (BAH1) domain and the replication foci targeting sequence (RFTS) of maintenance DNA methyltransferase DNMT1...

    Subject
    DNA (Cytosine-5-)-Methyltransferase 1
    DNA Methylation
    Heterochromatin
    Histone Code
    Histones
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  • Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting tumor mutation burden

    Authors
    Schvartzman, Juan-Manuel
    Koche, Richard Patrick
    Thompson, Craig B.
    Description

    Summary from GEO: "Oncogenic mutations in the metabolic enzyme isocitrate dehydrogenase 1 and 2 (IDH1/2) have been found in a number of liquid and solid tumors. Their pathogenic mechanism of action involves production of 2-hydroxyglutarate (2HG), an oncometabolite that acts in part by inhibiting members of a family of dioxygenases that modulate chromatin dynamics. Recent work has suggested that mutant...

    Subject
    DNA Replication
    Heterochromatin
    Isocitrate Dehydrogenase
    Poly ADP Ribosylation
    Poly(ADP-ribose) Polymerase Inhibitors
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    Free to All
  • The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

    Authors
    Batki, Julia
    Schnabl, Jakob
    Wang, Juncheng
    Handler, Dominik
    9 more author(s)...
    Description

    Summary from GEO: "The PIWI-interacting RNA (piRNA) pathway protects animal genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA- guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the subsequent molecular events are not understood. Here, we identify SFiNX (Silencing Factor interacting Nuclear eXport variant),...

    Subject
    Genomics
    Heterochromatin
    RNA Interference
    RNA-Binding Proteins
    RNA-Seq
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    Free to All
  • A nuclear RNA export factor variant licenses piRNA-guided heterochromatin formation

    Authors
    Imre, Richard
    Brennecke, Julius Fabian
    Description

    Description from PRIDE: "Small RNA silencing pathways protect genome integrity in part through establishing heterochromatin at transposon loci. In animals, this process requires piRNA-guided targeting of nuclear PIWI proteins to nascent transcripts. The molecular events contributing to heterochromatin formation upon PIWI binding to nascent RNA, a transient molecule at chromatin, are unknown. Here,...

    Subject
    Binding sites
    Heterochromatin
    Protein Conformation
    RNA Interference
    RNA-Binding Proteins
    RNA, Small Interfering
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    Free to All