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Data from: Differential requirements for the RAD51 paralogs in genome repair and maintenance in human cells
- Authors
- Garcin, Edwige B.Gon, StéphanieSullivan, Meghan R.Brunette, Gregory J.9 more author(s)...
- Description
From Dryad summary: "Abstract: Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF10A mammary epithelial cells and in transformed U2OS and HEK293 cells. In U2OS and HEK293 cells, viable...
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DNA-Binding ProteinsHomologous RecombinationRad51 Recombinase/deficiency
- Access Rights
- Free to All
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Senescence induction dictates response and resistance to chemo- and immunotherapy in preclinical models of ovarian cancer
- Authors
- Paffenholz, Stella V.Salvagno, CamillaHo, Yu-juiLimjoco, Matthew10 more author(s)...
- Description
Summary from GEO: "High-grade serous ovarian carcinoma (HGSOC) is associated with a dismal prognosis. While most patients initially respond to platinum-based chemotherapy, they almost always acquire resistance, and only a small subset of HGSOC patients benefit from immune checkpoint blockade (ICB). To elucidate the disease mechanisms and factors underlying sensitivity and resistance to conventional...
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Carcinoma, Ovarian EpithelialCellular SenescenceHomologous RecombinationImmune Checkpoint InhibitorsOvarian Neoplasms
- Access Rights
- Free to All
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A practical guide for mutational signature analysis in hematological malignancies
- Description
Description from EGA: "Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequencing of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia, we compare the...
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GenomicsHomologous RecombinationLeukemia, Lymphocytic, Chronic, B-CellMultiple MyelomaWhole Genome Sequencing
- Access Rights
- Application Required
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WGS short read and 10X linked read sequencing of HR Deficient breast cancers
- Description
Description from EGA: "A set of tumor/normal paired sequencing experiments, performed in short read WGS and 10X linked read whole genomes. BAM files aligned to hg19 are provided. Sample Alias number and Subject ID reflects patient of origin. T/N distinction discriminates between tumor and normal (peripheral blood) tissue."
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Breast NeoplasmsHomologous RecombinationWhole Genome Sequencing
- Access Rights
- Application Required
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setton_hadi_choo_2023
- Description
Description from GitHub: "This repository contains code and data to generate the figures presented in Setton, Hadi, Choo et al. Nature 2023. Most figures (aside from those which rely on random forest training) are found in ./notebooks/figures.ipynb. The remaining figures (Figure 5, Extended Data Figure 8, and Extended Data Figure 9) are found in ./notebooks/random_forest.ipynb. We have also made...
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Breast NeoplasmsChromosome BreakpointsHomologous RecombinationMachine LearningRandom Forest
- Access Rights
- Free to All