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Results Found: 5
  • Data from: Differential requirements for the RAD51 paralogs in genome repair and maintenance in human cells

    Authors
    Garcin, Edwige B.
    Gon, Stéphanie
    Sullivan, Meghan R.
    Brunette, Gregory J.
    9 more author(s)...
    Description

    From Dryad summary: "Abstract: Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants for each were generated in non-transformed MCF10A mammary epithelial cells and in transformed U2OS and HEK293 cells. In U2OS and HEK293 cells, viable...

    Subject
    DNA-Binding Proteins
    Homologous Recombination
    Rad51 Recombinase/deficiency
    Access Rights
    Free to All
  • Senescence induction dictates response and resistance to chemo- and immunotherapy in preclinical models of ovarian cancer

    Authors
    Paffenholz, Stella V.
    Salvagno, Camilla
    Ho, Yu-jui
    Limjoco, Matthew
    10 more author(s)...
    Description

    Summary from GEO: "High-grade serous ovarian carcinoma (HGSOC) is associated with a dismal prognosis. While most patients initially respond to platinum-based chemotherapy, they almost always acquire resistance, and only a small subset of HGSOC patients benefit from immune checkpoint blockade (ICB). To elucidate the disease mechanisms and factors underlying sensitivity and resistance to conventional...

    Subject
    Carcinoma, Ovarian Epithelial
    Cellular Senescence
    Homologous Recombination
    Immune Checkpoint Inhibitors
    Ovarian Neoplasms
    Access Rights
    Free to All
  • A practical guide for mutational signature analysis in hematological malignancies

    Description

    Description from EGA: "Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequencing of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia, we compare the...

    Subject
    Genomics
    Homologous Recombination
    Leukemia, Lymphocytic, Chronic, B-Cell
    Multiple Myeloma
    Whole Genome Sequencing
    Access Rights
    Application Required
  • WGS short read and 10X linked read sequencing of HR Deficient breast cancers

    Description

    Description from EGA: "A set of tumor/normal paired sequencing experiments, performed in short read WGS and 10X linked read whole genomes. BAM files aligned to hg19 are provided. Sample Alias number and Subject ID reflects patient of origin. T/N distinction discriminates between tumor and normal (peripheral blood) tissue."

    Subject
    Breast Neoplasms
    Homologous Recombination
    Whole Genome Sequencing
    Access Rights
    Application Required
  • setton_hadi_choo_2023

    Description

    Description from GitHub: "This repository contains code and data to generate the figures presented in Setton, Hadi, Choo et al. Nature 2023. Most figures (aside from those which rely on random forest training) are found in ./notebooks/figures.ipynb. The remaining figures (Figure 5, Extended Data Figure 8, and Extended Data Figure 9) are found in ./notebooks/random_forest.ipynb. We have also made...

    Subject
    Breast Neoplasms
    Chromosome Breakpoints
    Homologous Recombination
    Machine Learning
    Random Forest
    Access Rights
    Free to All