Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma

Authors

Lee, Ann Y.

Okada, Tomoyo

Agaram, Narasimhan

Qin, Li-Xuan

11 more author(s)...

Description

Summary from GEO: "Analysis of U133A microarray data from 64 primary high-grade tumors identified ITGA10 as the gene most significantly associated with distant metastasis and poor disease-specific survival. Further investigation using shRNA knockdown identifies the TRIO-RAC-PAK and RICTOR-mTORC2 pathways as important downstream signaling pathways for ITGA10." Overall design from GEO: "RNA samples...

Subject

Fibrosarcoma

Integrin alpha Chains

Neoplasm Metastasis

Survival Analysis

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