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  • Accumulated ion monitoring for improved sensitivity

    Authors
    Kentsis, Alex
    Description

    This work aimed to improve sensitivity of targeted detection by orbitrap mass spectrometers. Co-isolation of contaminant ions was identified as the major factor limiting sensitivity, and LOD of both PRM and accumulated precursor ion scanning (AIM) was improved by increased chromatographic resolution.

    Subject
    Ions
    Liquid Chromatography-Mass Spectrometry
    Peptides
    Proteomics
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