Accumulated ion monitoring for improved sensitivity

Authors

Kentsis, Alex

Description

This work aimed to improve sensitivity of targeted detection by orbitrap mass spectrometers. Co-isolation of contaminant ions was identified as the major factor limiting sensitivity, and LOD of both PRM and accumulated precursor ion scanning (AIM) was improved by increased chromatographic resolution.

Subject

Ions

Liquid Chromatography-Mass Spectrometry

Peptides

Proteomics

Access Rights

Free to All