GABA regulates electrical activity and tumor initiation in melanoma

Authors

Tagore, Mohita

White, Richard Mark

Description

Summary from GEO: "Oncogenes can only initiate tumors in certain cellular contexts, which is referred to as oncogenic competence. In melanoma, whether cells in the microenvironment can endow such competence remains unclear. Using a combination of zebrafish transgenesis coupled with human tissues, we demonstrate that GABAergic signaling between keratinocytes and melanocytes promotes melanoma initiation...

Subject

gamma-Aminobutyric Acid

Keratinocytes

Melanoma

Microscopy, Electron

Sequence Analysis, RNA

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