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pre-GC and GC B cell scRNAseq
- Alternate Title(s)
- Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
- Authors
- Smolkin, RyanSharma, RahulChaudhuri, Jayanta
- Description
Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...
- Subject
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B-LymphocytesGerminal CenterLactate DehydrogenasesLymphocyte ActivationSingle-Cell Gene Expression AnalysisT-Lymphocytes
- Access Rights
- Free to All
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High-throughput JH4 sequencing of germinal centers of LDHA-suffiicient and -deficient B cells
- Alternate Title(s)
- Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
- Authors
- Smolkin, RyanFernandez, Keith ConradSharma, RahulChaudhuri, Jayanta
- Description
Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...
- Subject
-
B-LymphocytesGerminal CenterLactate DehydrogenasesLymphocyte ActivationT-Lymphocytes
- Access Rights
- Free to All
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GC B cell RNAseq
- Alternate Title(s)
- Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
- Authors
- Smolkin, RyanSharma, RahulChaudhuri, Jayanta
- Description
Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...
- Subject
-
B-LymphocytesGerminal CenterLactate DehydrogenasesLymphocyte ActivationRNA-SeqT-Lymphocytes
- Access Rights
- Free to All
