Lipid droplets are a metabolic vulnerability in melanoma

Authors

Lumaquin-Yin, Dianne

White, Richard Mark

Description

Summary from GEO: "Melanoma exhibits numerous transcriptional cell states including neural crest-like cells as well as pigmented melanocytic cells. How these different cell states relate to distinct tumorigenic phenotypes remains unclear. Here, we use a zebrafish melanoma model to identify a transcriptional program linking the melanocytic cell state to a dependence on lipid droplets, the specialized...

Subject

Fatty Acids/metabolism

Lipid Droplets

Lipid Droplets/metabolism

Melanocytes

Melanoma

RNA-Seq

Access Rights

Free to All