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Results Found: 4
  • pre-GC and GC B cell scRNAseq

    Alternate Title(s)
    Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
    Authors
    Smolkin, Ryan
    Sharma, Rahul
    Chaudhuri, Jayanta
    Description

    Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...

    Subject
    B-Lymphocytes
    Germinal Center
    Lactate Dehydrogenases
    Lymphocyte Activation
    Single-Cell Gene Expression Analysis
    T-Lymphocytes
    Access Rights
    Free to All
  • High-throughput JH4 sequencing of germinal centers of LDHA-suffiicient and -deficient B cells

    Alternate Title(s)
    Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
    Authors
    Smolkin, Ryan
    Fernandez, Keith Conrad
    Sharma, Rahul
    Chaudhuri, Jayanta
    Description

    Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...

    Subject
    B-Lymphocytes
    Germinal Center
    Lactate Dehydrogenases
    Lymphocyte Activation
    T-Lymphocytes
    Access Rights
    Free to All
  • GC B cell RNAseq

    Alternate Title(s)
    Distinct Metabolic Requirements Regulate B Cell Activation and Germinal Center Responses
    Authors
    Smolkin, Ryan
    Sharma, Rahul
    Chaudhuri, Jayanta
    Description

    Summary from GEO: "Following infection or vaccination, activated B cells at extrafollicular sites or within germinal centers (GCs) undergo vigorous clonal proliferation. Proliferating lymphocytes have been shown to undertake lactate dehydrogenase A (LDHA)-dependent aerobic glycolysis; however, the specific role of this metabolic pathway in a B cell transitioning from a naïve to a highly proliferative,...

    Subject
    B-Lymphocytes
    Germinal Center
    Lactate Dehydrogenases
    Lymphocyte Activation
    RNA-Seq
    T-Lymphocytes
    Access Rights
    Free to All
  • Avidity Selection of Natural Killer Response to MCMV

    Authors
    Santosa, Endi K
    Sun, Joseph C.
    Description

    Summary from GEO: "Natural killer (NK) cells are innate lymphocytes that possess features of adaptive immunity, such as the ability to recognize specific antigen, among others. In MCMV infection, the engagement of a subset of NK cells expressing an activating receptor Ly49H with MCMV-derived glycoprotein m157 results in a clonal-like expansion and the generation of a small pool of long-lived memory...

    Subject
    Cytomegalovirus
    Glycoproteins
    Killer Cells, Natural
    Lymphocyte Activation
    RNA-Seq
    Access Rights
    Free to All