-
Effect of MYC expression on mouse PyMT tumor
- Authors
- Zhang, XianLi, Ming O.
- Description
Summary from GEO: "S100a8-cre driven expression of Rosa26-LSL-MYC in mouse PyMT cancer cells." Overall design from GEO: "Bulk tumor tissues from control-PyMT and S100a8-creRosa26-LSL-MYCPyMT (MYC-PyMT) mice were collected and homogenized in liquid nitrogen for TRIZOL RNA extraction and RNAseq."
- Subject
-
Gene ExpressionGenes, mycMice, TransgenicRNA-Seq
- Access Rights
- Free to All
-
Gene expression profile at single nucleus level for tumor associated macrophage (TAMs) nuclei sorted from tumor of control-PyMT and S100a8-creRosa26-LSL-MYCPyMT (MYC-PyMT) mice treated with low protein diet
- Authors
- Zhang, XianLi, Ming O.
- Description
Summary from GEO: "Nuclei of TAMs were sorted for single nucleus RNA sequencing from control-PyMT and MYC-PyMT tumor treated with low protein diet, and compare their transcriptome differences." Overall design from GEO: "7-week-old Control-PyMT and MYC-PyMT mice were lethally irradiated and reconstituted with 3 million total bone marrow cells from Fcgr1-cre-Rosa26LSL-H2B-mCherry/+ mice as described...
- Subject
-
Diet, Protein-RestrictedGene ExpressionMice, TransgenicSingle-Cell Gene Expression AnalysisTranscriptomeTumor-Associated Macrophages
- Access Rights
- Free to All
-
Effect of low protein diet on parenchymal tumor associated macrophages (TAMs) and stromal mammary tissue macrophages (MTMs) in control-PyMT and MYC overexpressing PyMT ( S100a8-creRosa26-LSL-MYCPyMT ) tumor
- Authors
- Zhang, XianLi, Ming O.
- Description
Summary from GEO: "To study the low protein diet and cancer genetic effect on the macrophage in tumor, we treated the control-PyMT and S100a8-creRosa26-LSL-MYCPyMT (MYC-PyMT) mice reconstituted with wt bone marrow with low protein diet for 6 weeks." Overall design from GEO: "Compare the gene expression between TAMs and MTMs isolated by FACS from tumor of control-PyMT and MYC-PyMT mice treated...
- Subject
-
Diet, Protein-RestrictedGene ExpressionGenes, mycMice, TransgenicTumor-Associated Macrophages