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  • Regenerative origin of metastasis stem cells

    Authors
    Ganesh, Karuna
    Massagué, Joan
    Koche, Richard Patrick
    Reuter, Vincent Patrick
    Description

    Author summary from Gene Expression Omnibus: "Assaying binding of REST to DNA with ChIP-seq reveals the role of REST in transcriptional regulation in colorectal cancer (CRC) metastatic stem cells (MetSCs). REST is especially relevant to regulation of L1CAM expression." Overall Design: "ChIP-seq of binding of REST to DNA." Abstract summary: "Metastasis-initiating cells with stem-like properties drive...

    Subject
    Colorectal Neoplasms
    Neoplastic Stem Cells
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    Free to All
  • Quiescent human glioblastoma cancer stem cells mediate tumor initiation, expansion, and recurrence following chemotherapy

    Authors
    Xie, Xuanhua P.
    Laks, Dan R.
    Ganbold, Mungunsarnai
    Parada, Luis F.
    Description

    Summary from GEO: "We performed single cell RNA sequencing with eight patient derived xenograft samples to identify quiescent cancer stem cells in glioblastoma. Additionally two samples treated with temozolomide was sequenced to examine the evolution of the cancer stem cells upon chemotherapeutics." Overall design from GEO: "Whole transcriptome single cell RNA sequencing with 10X method."

    Subject
    Glioblastoma
    Glioblastoma/drug therapy
    Heterografts
    Neoplastic Stem Cells
    Single-Cell Gene Expression Analysis
    Transcriptome
    Access Rights
    Free to All