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Regenerative origin of metastasis stem cells
- Authors
- Ganesh, KarunaMassagué, JoanKoche, Richard PatrickReuter, Vincent Patrick
- Description
Author summary from Gene Expression Omnibus: "Assaying binding of REST to DNA with ChIP-seq reveals the role of REST in transcriptional regulation in colorectal cancer (CRC) metastatic stem cells (MetSCs). REST is especially relevant to regulation of L1CAM expression." Overall Design: "ChIP-seq of binding of REST to DNA." Abstract summary: "Metastasis-initiating cells with stem-like properties drive...
- Subject
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Colorectal NeoplasmsNeoplastic Stem Cells
- Access Rights
- Free to All
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Quiescent human glioblastoma cancer stem cells mediate tumor initiation, expansion, and recurrence following chemotherapy
- Authors
- Xie, Xuanhua P.Laks, Dan R.Ganbold, MungunsarnaiParada, Luis F.
- Description
Summary from GEO: "We performed single cell RNA sequencing with eight patient derived xenograft samples to identify quiescent cancer stem cells in glioblastoma. Additionally two samples treated with temozolomide was sequenced to examine the evolution of the cancer stem cells upon chemotherapeutics." Overall design from GEO: "Whole transcriptome single cell RNA sequencing with 10X method."
- Subject
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GlioblastomaGlioblastoma/drug therapyHeterograftsNeoplastic Stem CellsSingle-Cell Gene Expression AnalysisTranscriptome
- Access Rights
- Free to All