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  • Table S5 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S5. Nonsynonymous single nucleotide variants (SNVs) and insertions/deletions (indels) identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Exome Sequencing
    Neoplasms/drug therapy
    Nucleotides
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Intrinsic Coupling of Lagging Strand Synthesis to Chromatin Assembly

    Authors
    Smith, Duncan J.
    McGuffee, S.
    Whitehouse, Iestyn
    Description

    Summary from GEO: "We show that ligation-competent Okazaki fragments in Saccharomyces cerevisiae are sized according to the chromatin repeat. Using deep sequencing, we demonstrate that ligation junctions preferentially occur around nucleosome midpoints rather than in internucleosomal linker regions. Disrupting chromatin assembly or lagging strand polymerase processivity impacts both the size and...

    Subject
    Chromatin
    Chromatin Assembly and Disassembly
    DNA Ligases
    DNA Replication
    Gene Knockout Techniques
    Nucleotides
    Access Rights
    Free to All