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Table S5 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations
- Authors
- Adib, ElioKlonowska, KatarzynaGiannikou, KrinioDo, Khanh T.15 more author(s)...
- Description
Description from Figshare: "Table S5. Nonsynonymous single nucleotide variants (SNVs) and insertions/deletions (indels) identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."
- Subject
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Clinical Trial, Phase IIEverolimusExome SequencingNeoplasms/drug therapyNucleotidesTOR Serine-Threonine Kinases
- Access Rights
- Free to All
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Intrinsic Coupling of Lagging Strand Synthesis to Chromatin Assembly
- Authors
- Smith, Duncan J.McGuffee, S.Whitehouse, Iestyn
- Description
Summary from GEO: "We show that ligation-competent Okazaki fragments in Saccharomyces cerevisiae are sized according to the chromatin repeat. Using deep sequencing, we demonstrate that ligation junctions preferentially occur around nucleosome midpoints rather than in internucleosomal linker regions. Disrupting chromatin assembly or lagging strand polymerase processivity impacts both the size and...
- Subject
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ChromatinChromatin Assembly and DisassemblyDNA LigasesDNA ReplicationGene Knockout TechniquesNucleotides
- Access Rights
- Free to All