Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication

Description

To date few DDK substrates other than the MCM helicase have been identified, and none are implicated in fork protection or restart. Here we searched for such factors, using SILAC and quantitative mass spectrometry to identify the DDK phosphoproteome during fork stalling.

Subject

DNA Replication

Immune Checkpoint Inhibitors

Mass spectrometry

Phosphopeptides

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