Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism

Authors

Vodnala, Suman Kumar

Description

Summary from the GEO: "The paradox of tumor immunology is that tumor infiltrating lymphocytes (TILs) are dysfunctional in situ and yet are capable of stem cell-like behavior with self-renewal, massive expansion, multipotency, and eradication of large metastatic tumors. Here we report that the overabundance of potassium in the tumor microenvironment (TME) can explain both phenomena." Overall design...

Subject

CD8-Positive T-Lymphocytes

Lymphocytes, Tumor-Infiltrating

Potassium

Tumor Microenvironment

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