Search Tips
of 1 Next >
Results Found: 3
  • Myelodysplastic (MSKCC, 2020): Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms

    Description

    This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.

    Subject
    Acute monoblastic/monocytic leukemia
    Anemia, Refractory
    Anemia, Refractory, with Excess of Blasts
    Anemia, Sideroblastic
    Leukemia, Erythroblastic, Acute
    Leukemia, Megakaryoblastic, Acute
    Leukemia, Myelogenous, Chronic, BCR-ABL Positive
    Leukemia, Myeloid, Acute
    Leukemia, Myelomonocytic, Acute
    Leukemia, Myelomonocytic, Chronic
    Mastocytosis
    Myelodysplastic Syndromes
    Myelodysplastic-Myeloproliferative Diseases
    Oncogene Proteins, Fusion
    Polycythemia Vera
    Primary Myelofibrosis
    Sarcoma, Myeloid
    Thrombocythemia, Essential
    Access Rights
    Free to All
    Local Expert
    Papaemmanuil, Elli
  • CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [ATAC-Seq]

    Authors
    Dunbar, Andrew
    Hoffman, Ronald
    Koche, Richard Patrick
    Levine, Ross L.
    Description

    Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...

    Subject
    Chromatin Immunoprecipitation Sequencing
    Interleukin-8
    Myeloproliferative Disorders
    Primary Myelofibrosis
    Receptors, Interleukin-8B
    Access Rights
    Free to All
  • CXCL8/CXCR2 signaling is Enriched in Fibrotic Myeloproliferative Neoplasms and is Vulnerable to Therapeutic Inhibition [RNA-Seq]

    Authors
    Dunbar, Andrew
    Koche, Richard Patrick
    Levine, Ross L.
    Hoffman, Ronald
    Description

    Summary from GEO: "Pro-inflammatory signaling is a hallmark feature of human cancer, including in myeloproliferative neoplasms (MPNs), most notably myelofibrosis (MF). Dysregulated inflammatory signaling contributes to fibrotic progression in MF; however, the individual cytokine mediators elicited by malignant MPN cells to promote collagen-producing fibrosis and disease evolution remain yet to be...

    Subject
    Interleukin-8
    Myeloproliferative Disorders
    Primary Myelofibrosis
    Receptors, Interleukin-8B
    RNA-Seq
    Access Rights
    Free to All