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Peptidomimetic blockade of MYB in acute myeloid leukemia [H3K27ac ChIP-seq]
- Authors
- Koche, Richard PatrickRamaswamy, KavithaKentsis, Alex
- Description
Summary from the GEO: "Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, in large part due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation with CREB-binding protein (CBP) is required for the initiation and maintenance of a variety of acute lymphoblastic and myeloid leukemias,...
- Subject
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Leukemia, Myeloid, Acutep300-CBP Transcription FactorsPeptidomimeticsProto-Oncogene Proteins c-myb
- Access Rights
- Free to All
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Peptidomimetic blockade of MYB in acute myeloid leukemia [MYB ChIP-seq]
- Authors
- Koche, Richard PatrickRamaswamy, KavithaKentsis, Alex
- Description
Summary from the GEO: "Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, in large part due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation with CREB-binding protein (CBP) is required for the initiation and maintenance of a variety of acute lymphoblastic and myeloid leukemias,...
- Subject
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Leukemia, Myeloid, Acutep300-CBP Transcription FactorsPeptidomimeticsProto-Oncogene Proteins c-myb
- Access Rights
- Free to All
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Peptidomimetic blockade of MYB in acute myeloid leukemia [RNA-seq]
- Authors
- Koche, Richard PatrickRamaswamy, KavithaKentsis, Alex
- Description
Summary from the GEO: "Aberrant gene expression is a hallmark of acute leukemias. However, therapeutic strategies for its blockade are generally lacking, in large part due to the pharmacologic challenges of drugging transcription factors. MYB-driven gene trans-activation with CREB-binding protein (CBP) is required for the initiation and maintenance of a variety of acute lymphoblastic and myeloid leukemias,...
- Subject
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Leukemia, Myeloid, Acutep300-CBP Transcription FactorsPeptidomimeticsProto-Oncogene Proteins c-myb
- Access Rights
- Free to All
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Peptidomimetic blockade of MYB in acute myeloid leukemia
- Description
Summary from the GEO: "This SuperSeries is composed of the SubSeries: GSE94240, GSE94241, GSE107078" A potential pharmacological therapeutic strategy for Acute Myeloid Leukemia (AML) was analyzed with the deposited experiments. Using structure-guided molecular design, a prototypical peptidomimetic inhibitor, MYBMIM, was developed and shown to interfere with the molecular assembly of AML cells. MYBMIM...
- Subject
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Leukemia, Myeloid, Acutep300-CBP Transcription FactorsPeptidomimeticsProto-Oncogene Proteins c-myb
- Access Rights
- Free to All
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Definition of aberrant MYB CBP/P300 complex in AML
- Authors
- Kentsis, Alex
- Description
Dysregulated gene expression is one of the most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of the MYB transcriptional co-activator complex. By rapid and selective peptidomimetic interference with the binding of CBP/P300 to MYB, but not CREB or MLL1, we find that the leukemic functions of MYB are mediated by...
- Subject
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Gene ExpressionLeukemia, Myeloid, Acutep300-CBP Transcription FactorsPeptidomimeticsProto-Oncogene Proteins c-myb
- Access Rights
- Free to All