Inhibition of MYC by the SMARCB1 tumor suppressor

Authors

Tansey, William

Weissmiller, April

Liu, Qi

Wang, Jing

Description

Summary from the GEO: "We report that the protein encoded by the SMARCB1 gene, SNF5, is capable of inhibiting MYC binding in vitro and in a malignant rhabdoid tumor (MRT) cell line. By comparing the effects of reintroduction of SNF5 with genetic inhibition of MYC (OMOMYC) on multiple aspects of chromatin remodeling and transcription in MRT cells, we show that regulation of MYC binding by SNF5 is not...

Subject

Chromatin

Chromatin Assembly and Disassembly

Proto-Oncogene Proteins c-myc

Rhabdoid Tumor

SMARCB1 Protein

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