Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts

Authors

Vedanayagam, Jeffrey

Lin, Ching-Jung

Papareddy, Ranjith

Nodine, Michael

3 more author(s)...

Description

Summary from GEO: "Although the biological utilities of endogenous RNAi (endo-RNAi) have been largely elusive, recent studies reveal its critical role in the non-model fruitfly Drosophila simulans to suppress selfish genes, whose unchecked activities can severely impair spermatogenesis. In particular, hairpin RNA (hpRNA) loci generate endo-siRNAs that suppress evolutionary novel, X-linked, meiotic...

Subject

Gene Expression

RNA Interference

RNA-Seq

RNA, Small Interfering

Spermatogenesis

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