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  • Table S5 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S5. Nonsynonymous single nucleotide variants (SNVs) and insertions/deletions (indels) identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Exome Sequencing
    Neoplasms/drug therapy
    Nucleotides
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S2 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S2. Demographic and clinical characteristics of 30 cancer patients with mTOR pathway mutations. S2.1. Master table showing a summary of demographic characteristics and clinical outcomes. S2.2. Prior systemic treatment regimens. S2.3. Objective response to everolimus according to RECIST v1.1 criteria. S2.4. Toxicity profile of patients according to CTCAE v4.0."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S3 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S3. Toxicities (any level) occurring in at least two patients, grouped by CTCAE v4.0 categories. For patients with more than one adverse event per category, only the highest-grade event was counted."

    Subject
    Clinical Trial, Phase II
    Drug-Related Side Effects and Adverse Reactions
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S6 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S6. Copy number alterations (CNAs) in cancer genes identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."

    Subject
    Clinical Trial, Phase II
    DNA Copy Number Variations
    Everolimus
    High-Throughput Nucleotide Sequencing
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S4 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare; "Table S4. Inactivating mutations in TSC1/TSC2 and activating mutation in MTOR identified in 30 patients in the clinical trial - clonality and biallelic TSC1/TSC2 inactivation status."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Tuberous Sclerosis Complex 1 Protein
    Tuberous Sclerosis Complex 2 Protein
    Access Rights
    Free to All
  • Table S1 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S1. Massively Parallel Sequencing (MPS) metrics and cancer sample characteristics."

    Subject
    Clinical Trial, Phase II
    Everolimus
    High-Throughput Nucleotide Sequencing
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Whole Genome and Exon Capture Sequencing of Bladder Cancers

    Authors
    Solit, David
    Taylor, Barry Stephen
    Description

    From the dbGaP study description: "One primary bladder cancer and paired peripheral blood sample were subjected to whole genome sequencing on an Illumina HiSeq 2000 platform. This technology was utilized to investigate the genetic basis of a durable remission of metastatic bladder cancer in a patient treated with everolimus, a drug that inhibits the mTOR (mammalian target of rapamycin) signaling...

    Subject
    Drug Therapy
    Neoplasm Metastasis
    TOR Serine-Threonine Kinases
    Urinary Bladder Neoplasms
    Whole Genome Sequencing
    Access Rights
    Application Required