Transfer of antigen target into CAR T cells via trogocytosis

Authors

Li, Zhuoning

Sadelain, Michel W. J.

Description

Description from PRIDE: "To characterize transfer of molecules from target cells into CAR T cells via trogocytosis we cultured NALM-6 leukemia cell line expressing a CD19-mCherry fusion protein with CAR T cells. NALM6-CD19-mCherry were loaded with heavy amino acid and cocultured with CAR T cells for 1 hour. CAR T cells were next sorted into two fractions, mCherry-positive (TrogPos), and -negative...

Subject

Leukemia

Proteomics

Receptors, Chimeric Antigen

T-Lymphocytes

Trogocytosis

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