Ultraviolet radiation drives mutations in a subset of mucosal melanomas

Description

Study Description from EGA: " Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We present the largest cohort of mucosal melanomas of conjunctival origin to be analyzed by whole genome sequencing and show a predominance of UVR-associated single base substitution signature...

Subject

Conjunctival Neoplasms

Melanoma

Ultraviolet Rays

Access Rights

Application Required