TMEM41B is a pan-flavivirus host factor

Authors

Hoffmann, H.-Heinrich

Schneider, William M.

Rozen-Gagnon, Kathryn

Miles, Linde A.

10 more author(s)...

Description

Summary from the GEO: "Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host factors required for flavivirus infection we performed full-genome loss of function CRISPR-Cas9 screens. Based on these results we focused our efforts on characterizing the roles that TMEM41B and VMP1...

Subject

CRISPR-Cas Systems

Flavivirus

Flavivirus Infections

Membrane Proteins

Polymorphism, Single Nucleotide

Virus Replication

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