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Results Found: 4
  • ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing

    Authors
    Lee, Seungjae
    Wei, Lu
    Zhang, Binglong
    Goering, Raeann
    4 more author(s)...
    Description

    Summary from GEO: "ELAV/Hu factors are conserved RNA binding proteins that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago. Nevertheless, still little is known about its impacts on the transcriptome, and potential functional overlap with its paralogs. Building on our recent findings that neural-specific...

    Subject
    3' Untranslated Regions
    Ectopic Gene Expression
    RNA Processing, Post-Transcriptional
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Overlapping activities of ELAV/Hu family RNA binding proteins specify the extended neuronal 3' UTR landscape in Drosophila [L1 CNS 3'seq]

    Authors
    Wei, Lu
    Lee, Seungjae
    Majumdar, Sonali
    Zhang, Binglong
    5 more author(s)...
    Description

    Summary from GEO: "The goal of this study is to perform quantitative comparison of transcriptome-wide 3'-end features of Drosophila melanogaster 1st instar larvae central neural system (L1CNS) from three genotypes: Canton-S, elav5 single mutant, and elav5/fne double mutant; Total RNAs were extracted from dissected L1CNS of Drosophila melanogaster Canton-S, elav5 single mutant, and elav5/fne double...

    Subject
    3' Untranslated Regions
    ELAV Proteins
    RNA 3' End Processing
    RNA-Binding Proteins
    Access Rights
    Free to All
  • Overlapping activities of ELAV/Hu family RNA binding proteins specify the extended neuronal 3' UTR landscape in Drosophila [L1 CNS RNA-seq]

    Authors
    Wei, Lu
    Lee, Seungjae
    Majumdar, Sonali
    Zhang, Binglong
    5 more author(s)...
    Description

    Summary from GEO: "The goals of this study are to perform quantitative comparison of whole transcriptome of Drosophila melanogaster 1st instar larvae central neural system (L1CNS) from three genotypes: Canton-S, elav5 single mutant, and elav5/fne double mutant; and the global 3'-end features of Drosophila melanogaster 1st instar larvae central neural system from three genotypes: Canton-S, elav5 single...

    Subject
    3' Untranslated Regions
    ELAV Proteins
    RNA 3' End Processing
    RNA-Binding Proteins
    RNA-Seq
    Access Rights
    Free to All
  • Overlapping activities of ELAV/Hu family RNA binding proteins specify the extended neuronal 3' UTR landscape in Drosophila [S2 3-seq]

    Authors
    Wei, Lu
    Lee, Seungjae
    Majumdar, Sonali
    Zhang, Binglong
    5 more author(s)...
    Description

    Summary from GEO: "The goals of this study are to establish a cell line based analysis platform to unbiasedly evaluate the capabilities of Elav/Hu family RNA binding proteins in regulating neural specific 3' UTR extension; and perform quantitative analysis of global 3' UTR extension regulated by individual Elav/Hu family RNA binding protein. We reported that in non-neural tissue context such as S2R+...

    Subject
    3' Untranslated Regions
    ELAV Proteins
    RNA 3' End Processing
    RNA-Binding Proteins
    Access Rights
    Free to All